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Best sinus medicines - June 2026

Last Updated - June 15, 2026

1
Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon One Medical

Sinus Infection Treatment & Symptoms | Request prescription for sinus medication like nasal spray, antibiotics for sinus headache & pain symptom relief from an online doctor, NP, or PA

Amazon One Medical

$39.00

More Details
Main highlights
- Treated with fda approved prescription drugs or otc medication like cleaner flush irrigation decongestant rinse clean out cefixime mometasone furoate Nasonex fluticasone propionate Flonase triamcinolone acetonide Nasacort intranasal ipratropium augmentin amoxicillin levaquin suprax omnicef oxymetazoline clavulanate doxycycline moxifloxacin levofloxacin cefdinir cefpodoxime clindamycin guaifenesin generic antibiotic
- Treated by online doctor, dr, MD, NP, PA. FSA/HSA reimburse for PPV. Adult human men man male hombre woman women
- Strengths like 100 mg 200 mg 250 mg 300 mg 400 mg 500 mg 600 mg 50 mcg 55 mcg 0.05 875 mg 125 mg 62.5 mg 5 ml 0.05%
- Pay per visit (PPV) telehealth telemedicine video, message. Membership option available. Previously Amazon Clinic
- Medicine forms like meds pills tablet tab capsule spray suspension
- Get medical care, diagnosis, remedy, relief, refill, help, cure sinus infection
$39.00
2

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Mucinex

Mucinex Maximum Strength Sinus-Max Severe Congestion & Pain + Nightshift Sinus Liquid, Cold and Flu Medicine for Adults, Over-the-Counter Medication for Multi-Symptom Relief, 2x6 Fl Oz

Mucinex

$19.97

$21.99
(9% Off)

More Details
Main highlights
- USAGE: Use as directed; For ages 12+ years
- SINUS SYMPTOM NIGHT RELIEF: Mucinex Nightshift Sinus reduces fever, relieves sore throat, runny nose, sneezing, nasal congestion, and controls cough
- SEVERE CONGESTION & PAIN SYMPTOM RELIEF: Maximum Strength Mucinex Sinus-Max Severe Congestion & Pain helps relieve headache, sinus congestion and thin & loosen mucus
- POWERFUL MULTI-SYMPTOM RELIEF: This combo pack of Maximum Strength Mucinex Sinus-Max Severe Congestion & Pain and Mucinex Nightshift Sinus provides powerful multi-symptom relief for your worst sinus congestion symptoms
- MUCINEX SINUS-MAX SEVERE CONGESTION & PAIN ACTIVE INGREDIENTS: Contains Acetaminophen - Pain reliever; Guaifenesin - Expectorant; Phenylephrine HCI - Nasal decongestant
- MUCINEX NIGHTSHIFT SINUS ACTIVE INGREDIENTS: Contains Acetaminophen - Pain reliever and fever reducer; Dextromethorphan HBr - Cough suppressant; Phenylephrine HCI - Nasal decongestant; Triprolidine HCl – Antihistamine
- #1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 Cold and Cough brand doctors trust* and #1 Pharmacist Recommended Brand
$19.97
$21.99 (9% Off)
3
Best Value
13% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Sudafed
13% Off

Sudafed PE Sinus Pressure Relief Plus Pain Relief Tablets, Maximum Strength, Non-Drowsy Decongestant, OTC Sinus Medicine with Acetaminophen and Phenylephrine HCl Nasal Decongestant, 24 CT

Sudafed

$9.26

$10.67
(13% Off)

More Details
Main highlights
- PHENYLEPHRINE HCL & ACETAMINOPHEN: Each sinus congestion and pressure relief tablet contains 5 mg of phenylephrine HCI, a nasal decongestant for non-drowsy relief, plus, 325 mg of acetaminophen, a pain & fever reducer
- NON-DROWSY COLD and SINUS MEDICINE: Sudafed sinus and pain medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold, plus sinus headaches
- HOW TO USE: Sudafed PE sinus pressure and pain relief congestion relief tablets can be used by adults and children ages 12 and up. Take two tablets every four hours; do not exceed 10 tablets within a 24 hour time
- FSA HSA APPROVED PRODUCT: Sinus congestion relief & pain medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure + Pain is HSA & FSA eligible** **Check your plan for details as plans may vary.
- DECONGESTANT & PAIN RELIEF: 24-count package of Sudafed PE Sinus Pressure and Pain maximum strength non-drowsy decongestant tablets for fast and powerful relief of sinus congestion, sinus pressure, and nasal congestion
$9.26
$10.67 (13% Off)
4

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Mucinex

Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

Mucinex

$13.96

More Details
Main highlights
- RAPID RELEASE CAPLETS: Mucinex Rapid Clear caplets start working fast
- PAIN RELIEF: Acetaminophen helps reduce fever and helps relieve body aches and headache associated with cold and flu
- MAXIMUM STRENGTH & NON-DROWSY: With Mucinex Rapid Clear, it's not "power through with a pounding headache" season—It's comeback season
- HEADACHE RELIEF: Helps relieve headaches including those associated with cold and flu
- EXPECTORANT: Contains Guaifenesin, an expectorant that aids in thinning and loosening mucus for more productive coughs and chest congestion relief
- EXCESS MUCUS RELIEF: The expectorant, Guaifenesin, provides effective excess mucus relief by thinning and loosening bothersome mucus in your chest, helping to clear chest congestion
- COLD MEDICINE: Mucinex Rapid Clear Pain, Headache, & Mucus Congestion is a trusted cold medicine for adults, offering comprehensive relief from cold and flu symptoms including fever, body pain, sore throat, headache, and excess mucus
$13.96
5

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Vicks

Vicks Sinex Severe Allergy & Sinus Nasal Spray, Original Ultra Fine Mist, Decongestant Relief from Nasal Congestion, Sinus Pressure Relief, 265 Sprays (2 Count)

Vicks

$14.97

More Details
Main highlights
- Vicks Sinex Severe Nasal Spray is HSA and FSA eligible, Check with your provider for more details
- Unlike nasal decongestant tablets, Vicks Sinex Severe Nasal Sprays works by delivering powerful decongestant medicine directly to your nasal membranes
- This powerful decongestant medicine be used to treat severe sinus congestion and pressure caused by a cold or seasonal allergy spell, Not intended for daily use
- Targets nasal congestion and sinus pressure at the source by reducing swelling in the sinuses
- Breathe better all day or all night long with Vicks Sinex Severe. For instant, 12-hour, nasal congestion and sinus pressure relief
$14.97

Best sinus medicines - June 2026

Sinus Infection Treatment & Symptoms | Request prescription for sinus medication like nasal spray, antibiotics for sinus headache & pain symptom relief from an online doctor, NP, or PA

Mucinex Maximum Strength Sinus-Max Severe Congestion & Pain + Nightshift Sinus Liquid, Cold and Flu Medicine for Adults, Over-the-Counter Medication for Multi-Symptom Relief, 2x6 Fl Oz

Sudafed PE Sinus Pressure Relief Plus Pain Relief Tablets, Maximum Strength, Non-Drowsy Decongestant, OTC Sinus Medicine with Acetaminophen and Phenylephrine HCl Nasal Decongestant, 24 CT

Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

Vicks Sinex Severe Allergy & Sinus Nasal Spray, Original Ultra Fine Mist, Decongestant Relief from Nasal Congestion, Sinus Pressure Relief, 265 Sprays (2 Count)

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Boiron SinusCalm Tablets for Sinus Pain Relief, Runny Nose, Congestion, Sinus Pressure, Headache - 60 Count

Sudafed PE Head Congestion Plus Mucus Relief Tablets for Sinus Pressure, Congestion and Headache, Non-Drowsy Decongestant with Acetaminophen, Guaifenesin, Phenylephrine HCI, 24 ct

GenCare Nasal Decongestant PE – Phenylephrine HCl 10mg Tablets (Bulk 300 Count) Non-Drowsy Sinus Pressure Relief & Nasal Congestion Relief, Stuffy Nose Decongestants for Adults – Compare to Sudafed PE

HealthA2Z® Decongestant PE | Phenylephrine HCl 10 mg | Nasal & Sinus Congestion Relief Due to Cold & Allergies (300 Count (Pack of 1))

Sudafed, PE Sinus Congestion Relief Tablets, Maximum Strength, Non-Drowsy 10 mg Phenylephrine HCI Decongestant for Sinus Pressure and Nasal Congestion Relief, Due to Cold or Allergies, 36 Count

Tylenol Sinus Severe Daytime Caplets, Non-Drowsy, Pain Reliever, Pressure and Nasal Congestion Relief, Fever Reducer, Expectorant, Acetaminophen, Guaifenesin, Phenylephrine HCL, 24 Count

ValuMeds Nasal Decongestant PE Non-Drowsy for Adults | Maximum Strength Phenylephrine HCl 10mg to Relieve Sinus Pressure from Cold or Allergies | Comparable to Sudafed PE Congestion | 100 Tablets

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Phenylephrine HCI 5mg, Nasal Decongestant for Sinus Pain, Headache & Nasal Congestion Relief, Fever Reduction, 24 Count

Vicks Sinex SEVERE LiquiCaps, All-In-One Sinus Relief, Non-Drowsy, Nasal Decongestant, Maximum Strength Relief of Sinus Headache, Pain, Pressure, & Congestion, 24 LiquiCaps

Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps

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