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Best refrigerated probiotics - Holiday Sale 2025

Last Updated - December 14, 2025

1
Best Choice

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Visbiome

Visbiome® GI Care - High Potency Probiotic - 112.5 Billion CFU Live Probiotics, Original De Simone Formulation, Made in USA, 60 Capsules.

Visbiome

$73.95

More Details
Main highlights
- SUSTAINABLY PACKAGED: Ships cold in a 100% curbside recyclable insulated cooler, equipped with ice packs and a temperature monitoring device, ensuring maximum potency upon arrival.
- QUALITY ASSURANCE: Proudly made in the USA. Packaged using Activ-Vial technology to safeguard live active properties from humidity damage. Suitable for lactose intolerant individuals.
- PURE & SAFE INGREDIENTS: Low-FODMAP Certified, Clean Label Certified, Non-GMO, Cornstarch Free, Gluten-Free. Non-active Ingredients: microcrystalline cellulose (derived from plant fiber), and vegetable capsule (hydroxypropyl methylcellulose). Note: Contains trace amounts of milk.
- PROVEN EFFICACY: Boasts over 100 human clinical trials as a recognized medical food.
- POWERFUL PROBIOTIC BLEND: Contains 8 clinically-tested strains with a potent 112.5 billion CFU per capsule. Designed for optimal gut health in both men and women.
- COLD STORAGE REQUIRED: Visbiome probiotics are shipped and stored under refrigerated conditions (36-46°F, 2-8°C) to ensure maximum potency, with the flexibility to remain effective at room temperature for up to one week.
$73.95
2

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Florajen

Florajen Acidophilus Probiotics, Gut Health, Vaginal Health, and Immune Support Supplement, Constipation and Bloating Relief for Adults, 90 Capsules (Refrigerated)

Florajen

$47.98

More Details
Main highlights
- Safe, Allergen-Free, & Non-GMO - Free from milk, eggs, gluten, & preservatives, Florajen Acidophilus is formulated without artificial colors or additives, ensuring safe, everyday use.
- Refrigerated for Maximum Potency & Freshness - Florajen Acidophilus is kept cold from manufacturing to delivery, ensuring live cultures retain their full potency, providing effective support for gut, immune, & vaginal health.
- High-Potency Probiotic Formula - Packed with billions of Lactobacillus acidophilus bacteria to help promote a natural balance of good bacteria, supporting digestive, urinary, & immune health.
- Comprehensive Health Support - Perfect for overall wellness, Florajen Acidophilus supports healthy digestion, reduces occasional bloating & constipation, & promotes vaginal & urinary health.
- Cold Chain Commitment for Consistency - Florajen guarantees maximum potency & consistency by keeping probiotics refrigerated throughout the entire process, ensuring optimal effectiveness through the expiration date.
$47.98
3

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Florajen

Florajen3 Digestion High Potency Refrigerated Probiotics | Restores Balance in Digestive System | for Antibiotic Side Effects | 60 Capsules

Florajen

$34.99

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Main highlights
- Helps restore and maintain the natural balance in the digestive system.
$34.99
4
13% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Physician's CHOICE
13% Off

Physician's CHOICE Probiotics 60 Billion CFU - 10 Strains + Organic Prebiotics - Immune, Digestive & Gut Health - Supports Occasional Constipation, Diarrhea, Gas & Bloating - for Women & Men - 60ct

Physician's CHOICE

$36.97

$42.52
(13% Off)

More Details
Main highlights
- Survives the Gut: From start to finish - this probiotic is designed to survive the gut & maximize the colonization of our strains. We use a shelf-stable bottle, acid-resistant capsules, and 60 Billion Colony forming units (CFU) to achieve this!
- Support Your Gut: Our probiotic contains 10 diverse high-quality probiotic strains and organic prebiotics - synergistically working together to support your gut health. Expertly crafted to support occasional constipation, diarrhea, gas & bloating!
- Safety Assured Standard of Quality: Our 60B probiotic is 3rd-party tested for purity and potency. Each bottle is manufactured with love & care in the USA with strict quality control - using imported and domestic ingredients.
- Max Strength General Probiotic 2 Month Supply (60ct) : Our probiotic is designed to support digestive health & gut health. A great choice for those looking to support a diverse healthy microbiome w/ 60B CFU - Probiotics for Women & Men alike. Same great product you love, with a new look. Packaging May Vary!
- Backed By Science - Our probiotics are crafted based on scientific research. We have partnered with a network of expert physicians to help review our products & research. We strive to educate & help you with informed decisions regarding your health.
$36.97
$42.52 (13% Off)
5
Best Value
14% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Garden of Life
14% Off

Garden of Life Raw Probiotics for Women and Men with Digestive Enzymes, 100 Billion CFU, Clinically Studied Strains, Shelf Stable, 30 Capsules

Garden of Life

$33.00

$38.49
(14% Off)

More Details
Main highlights
- RAW PROBIOTICS GARDEN OF LIFE: Many factors compromise your body's defenses; Help restore good bacteria in the GI tract with Clinically Studied B. lactis, L. acidophilus, L. paracasei and B. lactis—all in 1 small, easy to swallow capsule
- PROBIOTIC POTENCY GUARANTEED THROUGH EXPIRATION: This probiotic supplement's viability is maintained even if the product is warm for a few days during shipping; Shelf Stable
- DIGESTIVE ENZYME: The womens and mens probiotic includes a Protein-Digesting Enzyme Blend with Digestive Enzymes Protease, Acid Protease, and Protease S, to support healthy digestion and nutrient assimilation—plus a blend of Fruits and Vegetables
- CERTIFIED NON-GMO AND GLUTEN-FREE: The probiotics for women digestive health and men offers a high-quality care with its Non-GMO Project Verified and NSF Gluten-Free Certified, a raw formula that is free from binders, fillers, or carriers
- 100 BILLION PROBIOTIC FOR MEN AND WOMEN: A High Bifido formula with 100 Billion CFU Guaranteed and 34 Probiotic Strains to support healthy digestion and nutrient assimilation with our probiotics for digestive health
$33.00
$38.49 (14% Off)

Best refrigerated probiotics - Holiday Sale 2025

Visbiome® GI Care - High Potency Probiotic - 112.5 Billion CFU Live Probiotics, Original De Simone Formulation, Made in USA, 60 Capsules.

Florajen Acidophilus Probiotics, Gut Health, Vaginal Health, and Immune Support Supplement, Constipation and Bloating Relief for Adults, 90 Capsules (Refrigerated)

Florajen3 Digestion High Potency Refrigerated Probiotics | Restores Balance in Digestive System | for Antibiotic Side Effects | 60 Capsules

Physician's CHOICE Probiotics 60 Billion CFU - 10 Strains + Organic Prebiotics - Immune, Digestive & Gut Health - Supports Occasional Constipation, Diarrhea, Gas & Bloating - for Women & Men - 60ct

Garden of Life Raw Probiotics for Women and Men with Digestive Enzymes, 100 Billion CFU, Clinically Studied Strains, Shelf Stable, 30 Capsules

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VITALITOWN Probiotics 120 Billion CFUs | 36 Strains, with Prebiotics & Digestive Enzymes for Men Women | Shelf Stable | Digestive Health & Immune Support | Vegan, Non-GMO | 30 Delayed Release Veg Caps

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