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Best flea treatment for puppies - Holiday Sale 2025

Last Updated - December 14, 2025

1
Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advantage

Advantage II Small Dog Vet-Recommended Flea Treatment & Prevention | Dogs 3-10 lbs. | 4-Month Supply

Advantage

$50.98

More Details
Main highlights
- Vet recommended flea treatment and prevention for dogs at weighing 3 to 10 lbs., at least 7 weeks of age
- Same-day effectiveness, kills fleas within 12 hours of application and keeps working for 30 days
- Kills adult fleas, flea larvae and flea eggs for total flea prevention and treatment
- Fragrance-free formula, waterproof after 24 hours
- Easy-to-apply topical treatment, no prescription needed
$50.98
2

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Capstar

Capstar (Nitenpyram) Fast-Acting Oral Flea Treatment for Dogs 2-25 Lbs, Vet-Recommended Medication Tablets, Flea Tablets for Dogs Start Killing in 30 Minutes, 6 Doses

Capstar

$42.97

More Details
Main highlights
- Treat Reinfestations Fast: If your pet gets reinfested with fleas, simply give another dose of this flea treatment for dogs 2 to 25 lbs as often as once a day
- Tackle Flea Infestations Fast: With one dose of CAPSTAR flea medicine for dogs, you can watch the dead fleas fall off your pet
- No Prescription Needed: Fast, effective dog flea treatment that's available over the counter
- Intended Use: CAPSTAR for small dogs (57 mg) is safe for dogs and puppies 4 weeks and older that weigh 2-25 pounds
- Fast-Acting Dog Flea Medicine: CAPSTAR (nitenpyram for dogs) starts killing adult fleas in just 30 minutes
$42.97
3
Best Value
37% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Frontline
37% Off

FRONTLINE Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

Frontline

$27.99

$44.99
(37% Off)

More Details
Main highlights
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
- Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
- Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
$27.99
$44.99 (37% Off)
4

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basics

Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 Pounds), 3 Count, Packaging May Vary

Amazon Basics

$18.93

More Details
Main highlights
- WATERPROOF FORMULA: 24 hours after application your pet's treatment is protected against rain and water activities
- STABLE FORMULA: Amazon Basics Flea and Tick Topical does not expire
- SHIPMENT CONTAINS: One 3-dose pack of Amazon Basics Flea and Tick Treatment for Small Dogs (5-22 lbs)
- PACKAGING MAY VARY: Packaging may be different than what is shown but item and quality remain the same
- LONG-LASTING COVERAGE: One application provides up to 30 days of protection against pests, including deer ticks that may transmit Lyme disease
- FAST-ACTING FORMULA: Starts eliminating fleas and ticks within 24 hours of treatment
- COMPLETE PROTECTION: Active ingredients Fipronil and (s)-methoprene prevent flea infestations by killing flea eggs, flea larvae, biting flies and chewing lice
$18.93
5

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

PetArmor

PetArmor Plus Flea and Tick Prevention for Dogs, Small Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting (5-22 lbs)

PetArmor

$26.12

More Details
Main highlights
- Trusted, Vet Quality* Formula: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas within 24 hours
- Fast Acting Long-Lasting Dog Flea & Tick Control: One application of PetArmor Plus lasts up to 30 days providing nose to tail protection. A 3-dose package lasts three months
- Effective, Waterproof Flea Treatment for Dogs: PetArmor Plus small dog flea treatment is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application
- Easy-to-use, Long-Lasting: PetArmor Plus flea control for dogs comes with three (3) waterproof topical applications that provide your pet flea protection and control for three (3) months
- Break the Flea Cycle: Unlike other flea and tick treatments that may temporarily suppress activity, PETARMOR Plus dog flea & tick control works by effectively breaking the life cycle! Kill eggs and larvae to prevent reinfestation
$26.12

Best flea treatment for puppies - Holiday Sale 2025

Advantage II Small Dog Vet-Recommended Flea Treatment & Prevention | Dogs 3-10 lbs. | 4-Month Supply

Capstar (Nitenpyram) Fast-Acting Oral Flea Treatment for Dogs 2-25 Lbs, Vet-Recommended Medication Tablets, Flea Tablets for Dogs Start Killing in 30 Minutes, 6 Doses

FRONTLINE Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 Pounds), 3 Count, Packaging May Vary

PetArmor Plus Flea and Tick Prevention for Dogs, Small Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting (5-22 lbs)

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