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Best topical treatments - Holiday Sale 2025

Last Updated - December 14, 2025

1
Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

K9 Advantix

K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 lbs. | 4-Mo Supply

K9 Advantix

$57.48

More Details
Main highlights
- Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
- No prescription needed
- Kills fleas within 12 hours of application
- K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
- Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
$57.48
2
11% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Frontline
11% Off

FRONTLINE Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

Frontline

$39.98

$44.99
(11% Off)

More Details
Main highlights
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
- Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
- Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
$39.98
$44.99 (11% Off)
3

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basics

Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 pounds), 6 Count (Previously Solimo)

Amazon Basics

$29.25

$31.00
(5% Off)

More Details
Main highlights
- Waterproof: 24 hours after application your pet’s treatment is protected against rain and water activities
- Packaging received may vary: you may receive product in Solimo or Amazon Basics packaging
- One application provides up to 30 days of protection
- One 6 dose pack of Amazon Basics Flea and Tick Treatment for Dogs, Small (5-22 lbs), 6 Count (Previously Solimo)
- New Look, Same Formula: Packaging has changed, but the formula you know and love has remained the same
- Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
- Active ingredients (Fipronil and (s)-methoprene) prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
$29.25
$31.00 (5% Off)
4
Best Value
13% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

PetArmor
13% Off

PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs)

PetArmor

$24.99

$28.99
(13% Off)

More Details
Main highlights
- TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas within 24 hours.
- FAST ACTNG LONG-LASTING FLEA AND TICK PROTECTION: One application of PetArmor Plus lasts up to 30 days nose to tail. A 6-dose package lasts up to six months.
- EFFECTIVE, WATERPROOF FLEA TREATMENT FOR DOGS: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
- EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with three (3) waterproof topical applications that provides your pet flea protection and control for three (3) months.
- BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Dog Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation.
$24.99
$28.99 (13% Off)
5

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Topicals

Topicals High Roller Ingrown Hair Serum | Roll-on Tonic to Soothe and Calm Irritated Skin on Face, Armpits and Bikini Areas | Contains Salicylic and Glycolic Acid | Vegan and Cruelty-Free (1.7 Fl Oz)

Topicals

$26.00

More Details
Main highlights
- TOPICALS IS NOW ON AMAZON: Topicals the premium skin care brand is now available on Amazon! Our team at Topicals is dedicated to transforming the way you feel about skin through effective science-backed product & health advocacy! Results May Vary
- TARGETS BUILD UP: Our razor bump treatment is alcohol-free, fragrance-free, paraben-free, no synthetic dyes. It contains exfoliating, brightening, softening and moisturizing ingredients with multiple benefits that address a range of concerns.
- ROOTED IN SCIENCE: All Topicals products use ingredients & herbs that have been scientifically proven by clinical studies and formulated in partnership with our scientific advisory board. Topicals products are always free from dyes & animal testing.
- RAZOR BUMPS & IRRITATION? This lightweight, roll-on ingrown hair treatment is the sure bet to soothe shaving irritation & prevent bumps from ingrown hairs. Hygienic, easy-to use, mess-free package makes treating ingrown hair concerns a breeze.
- EASY TO USE: Just roll on this ingrown hair serum to clean, dry, affected areas 2-3 times per week or as needed. Allow to dry fully before layering other products or clothing. Use sunscreen and limit sun exposure. Stop use if irritation occurs
$26.00

Best topical treatments - Holiday Sale 2025

K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 lbs. | 4-Mo Supply

FRONTLINE Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 pounds), 6 Count (Previously Solimo)

PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs)

Topicals High Roller Ingrown Hair Serum | Roll-on Tonic to Soothe and Calm Irritated Skin on Face, Armpits and Bikini Areas | Contains Salicylic and Glycolic Acid | Vegan and Cruelty-Free (1.7 Fl Oz)

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Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 Pounds), 6 Count (Previously Solimo)

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