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Best topical flea treatment for cats - Holiday Sale 2025

Last Updated - December 14, 2025

1
Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

PetArmor

PetArmor Plus Flea and Tick Prevention for Cats over 1.5 lbs, Cat Flea and Tick Treatment, 6 Doses, Waterproof Topical, Fast Acting

PetArmor

$42.23

More Details
Main highlights
- TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Cats. PetArmor Plus for Cats has a powerful formula that starts to kill fleas within 24 hours.
- FLEA AND TICK PROTECTION: PetArmor Plus for Cats flea drops protects your furry family members from brown dog ticks, American dog ticks, Lone Star ticks, and deer ticks (which may transmit Lyme disease).
- EFFECTIVE, WATERPROOF FLEA TREATMENT FOR CATS: PetArmor Plus is a waterproof, flea & tick topical prevention for cats that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
- EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with six (6) waterproof topical applications that provide your pet flea protection and control for (6) months
- BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Cat Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation.
$42.23
2
11% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Frontline
11% Off

FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

Frontline

$39.98

$44.99
(11% Off)

More Details
Main highlights
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Cats can be used on kittens as young as eight weeks old, weighing 1.5 pounds or more; One monthly dose provides protection from fleas & ticks for a full 30 days
- Treat cats and dogs in the home monthly to effectively control fleas and ticks and prevent the establishment of new infestations
- Subscribe & save today to make it easier to keep your cat or dog protected year-round and make sure you never run out of FRONTLINE Plus
- FRONTLINE Plus for Cats provides waterproof, fast-acting, long-lasting flea and tick protection that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- FRONTLINE Plus also comes in a formula designed for dogs and puppies, 8 weeks and older, weighing 5 lbs and over, providing the same reliable flea & tick protection
- Even indoor dogs need flea and tick control because you or other pets in the household may bring fleas into the home; These fleas can lead to a flea infestation
- Break the flea life cycle with FRONTLINE Plus for Cats, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea & tick control
$39.98
$44.99 (11% Off)
3
Best Value
13% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basics
13% Off

Amazon Basics Flea and Tick Topical Treatment for Cats (Over 1.5 Pounds), 6 Count (Previously Solimo)

Amazon Basics

$18.58

$21.59
(13% Off)

More Details
Main highlights
- Waterproof: 24 hours after application your pet’s treatment is protected against rain and water activities
- Satisfaction Guarantee: We’re proud of our products. If you aren’t satisfied, we’ll refund you for any reason within a year of purchase. 1-877-485-0385
- Same product, new look―This product is identical in manufacturing and formulation as the Solimo brand
- Packaging received may vary: you may receive product in Solimo or Amazon Basics Packaging.
- One application provides up to 30 days of protection
- One 6 dose pack of Amazon Basics Flea & Tick Treatment for Cats (over 1.5 lbs)
- Amazon Basics Flea and Tick Topical does not expire
- Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
- Active ingredients (list ingredients) prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
$18.58
$21.59 (13% Off)
4

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basics

Amazon Basics Topical Flea Treatment for Large Cats (Over 9 Pounds), 4 Count (Previously Solimo)

Amazon Basics

$20.90

More Details
Main highlights
- TOPICAL CAT FLEA DROPS FOR REINFESTATION: This cat flea medicine proactively kills reinfesting fleas within 2 hours, efficiently halting the flea lifecycle
- SUITABLE CAT FLEA MEDS FOR LARGE CATS: Specifically formulated for cats weighing over 9 pounds, offering targeted flea control with our dedicated cat flea meds for your furry companion
- SUITABLE CAT FLEA MEDS FOR LARGE CATS: Specifically formulated for cats weighing over 9 pounds, offering targeted flea control with our dedicated cat flea meds for your furry companion
- LONG-LASTING FLEA PREVENTION FOR CATS: Protect your cat from infestations for up to 4 weeks with each application of this flea remover, providing continuous and reliable flea prevention for cats
- FAST-ACTING FLEA MEDICATION FOR CATS: Eliminates fleas in just 12 hours, providing your large cat with swift relief from discomfort with our effective flea medication for cats
$20.90
5

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basics

Amazon Basics Topical Flea Treatment for Large Cats (Over 9 Pounds), 6 Count (Previously Solimo

Amazon Basics

$28.50

More Details
Main highlights
- TOPICAL CAT FLEA DROPS FOR REINFESTATION: This cat flea medicine proactively kills reinfesting fleas within 2 hours, efficiently halting the flea lifecycle
- SUITABLE CAT FLEA MEDS FOR LARGE CATS: Specifically formulated for cats weighing over 9 pounds, offering targeted flea control with our dedicated cat flea meds for your furry companion
- NON-EXPIRING FLEA KILLER FOR CATS: Enjoy convenience with this flea medicine for cats that maintains its effectiveness over time, without the worry of expiration dates or decreased performance
- LONG-LASTING FLEA PREVENTION FOR CATS: Protect your cat from infestations for up to 4 weeks with each application of this flea remover, providing continuous and reliable flea prevention for cats
- FAST-ACTING FLEA MEDICATION FOR CATS: Eliminates fleas in just 12 hours, providing your large cat with swift relief from discomfort with our effective flea medication for cats
$28.50

Best topical flea treatment for cats - Holiday Sale 2025

PetArmor Plus Flea and Tick Prevention for Cats over 1.5 lbs, Cat Flea and Tick Treatment, 6 Doses, Waterproof Topical, Fast Acting

FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

Amazon Basics Flea and Tick Topical Treatment for Cats (Over 1.5 Pounds), 6 Count (Previously Solimo)

Amazon Basics Topical Flea Treatment for Large Cats (Over 9 Pounds), 4 Count (Previously Solimo)

Amazon Basics Topical Flea Treatment for Large Cats (Over 9 Pounds), 6 Count (Previously Solimo

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