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Best otc medicinal sleep aids - Holiday Sale 2025

Last Updated - December 14, 2025

1
Best Choice

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Unisom

Unisom Nighttime Sleep-Aid Gels, Diphenhydramine HCI 50mg, 100 Count, 2 pk

Unisom

$34.96

More Details
Main highlights
- TRUST UNISOM, THE SLEEP EXPERT: The Pharmacist Recommended OTC Sleep-Aid Brand Data represents brand/product selections from the 2019 Pharmacy Times Survey of Pharmacists' OTC Recommendations
- NON-HABIT FORMING: Liquid-filled SoftGels are safe if used as directed, non-habit forming and help you sleep soundly
- INCLUDES: Two (2) bottles with 100 SoftGels of Unisom SleepGels Nighttime Sleep-aid; one SoftGel per dose
- FIND A NIGHTTIME SLEEP SOLUTION THAT'S RIGHT FOR YOU: Millions of people turn to Unisom for a restful night's sleep; Unisom SleepGels, SleepTabs, SleepMinis, SleepMelts or PM Pain can help you take on your day
- A STRESSFUL DAY DESERVES A RESTFUL NIGHT: Unisom helps you fall asleep fast and get a good night's sleep to recharge and restore
$34.96
2

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Relaxium

Relaxium Sleep Aid – Professional Strength Formula for Adults | 5mg Melatonin, Magnesium Glycinate, Valerest & Ashwagandha | Non-Habit Forming Sleep Support | 60 Capsules, 30-Day Supply

Relaxium

$29.99

More Details
Main highlights
- MONEY-BACK GUARANTEE: We're so confident in the effectiveness of Relaxium Sleep that we back it up with a money-back guarantee. For refunds within 30 days of purchase please contact Amazon through your account or reach out to our customer support team members.
- FALL ASLEEP, STAY ASLEEP: Relaxium's Triple-Action formula is formulated to help you wake up each morning without feeling groggy by restoring your natural sleep cycle, relaxing the body, and calming the mind; This sleep supplement is non-habit forming and easy-to-swallow; It is your worry-free answer to getting a better night's sleep.
- FALL ASLEEP FASTER, AWAKE REVITALIZED: Relaxium's Triple-Action formula is designed to help you wake up each morning feeling refresh and non-groggy by restoring your natural sleep cycle, relaxing the body, and calming the mind.
- DEVELOPED BY A RENOWNED NEUROLOGIST: Dr. Eric Ciliberti, MD developed Relaxium Sleep to help his patients and millions of others who suffer from lack of sleep; This sleep aid has the perfect synergistic blend of melatonin, magnesium, passionflower, GABA, Ashwagandha, and chamomile to fight your nighttime woes; It is the ONLY sleep solution that contains a proprietary ingredient, Valerest to help induce sleep safely.
- Consult your health care provider before taking any supplements, especially if you’re taking prescription medications, are pregnant or nursing.
- BOOST IMMUNE HEALTH W/ BETTER SLEEP: Sleep deprivation is known to suppress our body's natural immune function, and sleeping better helps support a stronger immune system; More than ever it's essential that you make Relaxium Sleep part of your daily routine to assure the deep rejuvenating sleep your body and mind needs.
$29.99
3

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basic Care

Amazon Basic Care Nighttime Sleep Aid Tablets for Adults, Doxylamine Succinate 25 mg, 96 Count

Amazon Basic Care

$11.74

More Details
Main highlights
- THE ACTIVE INGREDIENT in Amazon Basic Care Sleep Aid Tablets is doxylamine succinate 25 mg, a nighttime sleep aid which compares to the active ingredient in Unisom SleepTabs
- TESTED & EFFECTIVE: Clinically tested and proven effective, doxylamine succinate 25 mg sleep aid tablets are for adults and children ages 12 years and older
- NIGHTTIME SLEEP AID: With just one tablet per dose, Amazon Basic Care Sleep Aid Tablets, Doxylamine Succinate Tablets 25 mg help to reduce difficulty in falling asleep. Use as a nighttime sleep aid
- FOCUS ON SLEEP: With a single one-tablet dose, Amazon Basic Care Sleep Aid Tablets with doxylamine succinate 25 mg as the active ingredient help reduce difficulty in falling asleep. This nighttime sleep aid contains no pain reliever and is gluten free
- FALL ASLEEP: Sleep is important. One tablet per dose helps to reduce difficulty falling asleep. Gluten free
$11.74
4
Best Value
17% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Relaxium
17% Off

Relaxium Sleep Aid for Adults, Melatonin 5mg with Magnesium Glycinate, Sleep-Promoting Valerest & Ashwagandha, Non-Habit Forming Sleep Supplement, 60 Capsules, 30-Day Supply

Relaxium

$28.90

$34.99
(17% Off)

More Details
Main highlights
- MONEY-BACK GUARANTEE: We're so confident in the effectiveness of Relaxium Sleep that we back it up with a money-back guarantee. For refunds within 30 days of purchase please contact Amazon through your account or reach out to our customer support team members.
- FALL ASLEEP, STAY ASLEEP: Relaxium's Triple-Action formula is guaranteed to help you wake up each morning without feeling groggy by restoring your natural sleep cycle, relaxing the body, and calming the mind; This sleep supplement is non-habit forming and easy-to-swallow; It is your worry-free answer to getting a better night's sleep.
- FALL ASLEEP FASTER, STAY ASLEEP LONGER, AWAKE REVITALIZED: Relaxium's Triple-Action formula is designed to help you wake up each morning feeling refresh and non-groggy by restoring your natural sleep cycle, relaxing the body, and calming the mind.
- DEVELOPED BY A RENOWNED NEUROLOGIST: Dr. Eric Ciliberti, MD developed Relaxium Sleep to help his patients and millions of others who suffer from lack of sleep; This sleep aid has the perfect synergistic blend of melatonin, magnesium, passionflower, GABA, Ashwagandha, and chamomile to fight your nighttime woes; It is the ONLY sleep solution that contains a proprietary ingredient, Valerest to help induce sleep safely.
- Consult your health care provider before taking any supplements, especially if you’re taking prescription medications, are pregnant or nursing.
- BOOST IMMUNE HEALTH W/ BETTER SLEEP: Sleep deprivation is known to suppress our body's natural immune function, and sleeping better helps support a stronger immune system; More than ever it's essential that you make Relaxium Sleep part of your daily routine to assure the deep rejuvenating sleep your body and mind needs.
$28.90
$34.99 (17% Off)
5

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

MEDCHOICE

12-in-1 Melatonin Sleep Capsules - Natural Sleep Aids for Adults with Melatonin 5mg and Magnesium Glycinate 500mg, Sleep Aid with Ashwagandha, L Theanine, Valerian Root, GABA, 5-HTP (90ct, Pack of 1)

MEDCHOICE

$22.95

More Details
Main highlights
- Tranquil Nights Ahead - Vegan melatonin reinforces your calming sleep routines. Serene nights await, thanks to GABA and Chamomile, alongside Valerian root 10:1 extract that’s 10 times more potent than our previous blend.
- Sleep Like You Mean It - We've improved the formula of our melatonin capsules for adults seeking a non-habit-forming way to get their well-deserved rest and feel ready to take on their day in the morning.
- Packaging Update: We’ve updated our product label to reflect a revised mg-per-serving amount (from 2915 mg to 1115 mg). Please note: the ingredients, formula, serving size, and supplement facts have not changed. You may receive either label during this transition period — both versions are authentic and reflect the same high-quality product.
- Ingredients of Your Dreams - Our sleep aid supplement contains 5mg of melatonin, 500mg of Magnesium Glycinate, Ashwagandha, and Black Pepper extracts. It's a nightly routine that leaves you energized every morning.
- Benefits You Can Feel – L-Theanine is known to encourage alpha brain wave activity, often linked with calmness. Magnesium glycinate is a gentle, bioavailable form of magnesium that helps support relaxation as part of a nighttime routine.
$22.95

Best otc medicinal sleep aids - Holiday Sale 2025

Unisom Nighttime Sleep-Aid Gels, Diphenhydramine HCI 50mg, 100 Count, 2 pk

Relaxium Sleep Aid – Professional Strength Formula for Adults | 5mg Melatonin, Magnesium Glycinate, Valerest & Ashwagandha | Non-Habit Forming Sleep Support | 60 Capsules, 30-Day Supply

Amazon Basic Care Nighttime Sleep Aid Tablets for Adults, Doxylamine Succinate 25 mg, 96 Count

Relaxium Sleep Aid for Adults, Melatonin 5mg with Magnesium Glycinate, Sleep-Promoting Valerest & Ashwagandha, Non-Habit Forming Sleep Supplement, 60 Capsules, 30-Day Supply

12-in-1 Melatonin Sleep Capsules - Natural Sleep Aids for Adults with Melatonin 5mg and Magnesium Glycinate 500mg, Sleep Aid with Ashwagandha, L Theanine, Valerian Root, GABA, 5-HTP (90ct, Pack of 1)

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