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Best flea treatment for indoor cats - Holiday Sale 2025

Last Updated - December 14, 2025

1
Best Choice

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply

Advantage

$68.98

More Details
Main highlights
- Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
- Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
- Fragrance-free formula, waterproof after 24 hours of application
- Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
- Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
$68.98
2

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 4-Month Supply

Advantage

$51.98

More Details
Main highlights
- Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
- Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
- Fragrance-free formula, waterproof after 24 hours of application
- Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
- Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
$51.98
3

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply

Advantage

$33.58

More Details
Main highlights
- Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
- Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
- Fragrance-free formula, waterproof after 24 hours of application
- Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
- Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
$33.58
4
Best Value
11% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Frontline
11% Off

FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

Frontline

$39.98

$44.99
(11% Off)

More Details
Main highlights
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Cats can be used on kittens as young as eight weeks old, weighing 1.5 pounds or more; One monthly dose provides protection from fleas & ticks for a full 30 days
- Treat cats and dogs in the home monthly to effectively control fleas and ticks and prevent the establishment of new infestations
- Subscribe & save today to make it easier to keep your cat or dog protected year-round and make sure you never run out of FRONTLINE Plus
- FRONTLINE Plus for Cats provides waterproof, fast-acting, long-lasting flea and tick protection that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- FRONTLINE Plus also comes in a formula designed for dogs and puppies, 8 weeks and older, weighing 5 lbs and over, providing the same reliable flea & tick protection
- Even indoor dogs need flea and tick control because you or other pets in the household may bring fleas into the home; These fleas can lead to a flea infestation
- Break the flea life cycle with FRONTLINE Plus for Cats, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea & tick control
$39.98
$44.99 (11% Off)
5

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advantage

Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention | Cats 5-9 lbs. | 2-Month Supply

Advantage

$33.58

More Details
Main highlights
- Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
- Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
- Fragrance-free formula, waterproof after 24 hours of application
- Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
- Advantage II Small Cat is a leading brand in cat flea treatment and prevention for small cats 5-9 lbs., at least 8 weeks of age
$33.58

Best flea treatment for indoor cats - Holiday Sale 2025

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 4-Month Supply

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply

FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention | Cats 5-9 lbs. | 2-Month Supply

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