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Best flea treatment for cats - Holiday Sale 2025

Last Updated - December 14, 2025

1
Best Choice

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advantage

Advantage XD Small Cat Flea Prevention & Treatment For Cats 1.8-9lbs. | 2-Topical Doses, 2-Months of Protection Per Dose

Advantage

$55.98

More Details
Main highlights
- Longer-lasting protection vs. other topical products;* 2 months protection per dose, outlasting the typical flea life cycle *Based on label claims
- Fragrance-free formula, containing a naturally derived ingredient Spinetoram - winner of a Green Chemistry award** **US EPA Presidential Green Chemistry Challenge. Designing Greener Chemicals Award. 2008.
- Fast-acting treatment starts killing fleas within 30 minutes to 4 hours through contact
- Easy-to-apply topical treatment, no prescription needed
- 4 months (2 doses) flea treatment and prevention for indoor and outdoor cats and kittens 1.8-9 lbs., 8 weeks or older
$55.98
2

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Capstar

Capstar (nitenpyram) Cat Flea Treatment, Fast-Acting Oral Flea Treatment for Cats 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 6 Doses

Capstar

$42.96

More Details
Main highlights
- With one dose of CAPSTAR cat flea medication, you can watch the dead fleas fall off your pet
- If your pet gets reinfested with fleas, simply give another dose of the cat flea pills as often as once a day
- CAPSTAR oral cat flea treatment (11.4 mg) is safe for cats and kittens 4 weeks and older that weigh 2-25 pounds
- CAPSTAR nitenpyram for cats is a fast, effective flea treatment that is available over the counter
- CAPSTAR for cats (nitenpyram) starts killing adult fleas in just 30 minutes
$42.96
3

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 1-Month Supply

Advantage

$16.98

More Details
Main highlights
- Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
- Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
- Fragrance-free formula, waterproof after 24 hours of application
- Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
- Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
$16.98
4

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basics

Amazon Basics PreventativeTopical Flea Treatment for Large Cats (Over 9 Pounds), 4 Count

Amazon Basics

$20.90

More Details
Main highlights
- TOPICAL CAT FLEA DROPS FOR REINFESTATION: This cat flea medicine proactively kills reinfesting fleas within 2 hours, efficiently halting the flea lifecycle
- SUITABLE CAT FLEA MEDS FOR LARGE CATS: Specifically formulated for cats weighing over 9 pounds, offering targeted flea control with our dedicated cat flea meds for your furry companion
- SUITABLE CAT FLEA MEDS FOR LARGE CATS: Specifically formulated for cats weighing over 9 pounds, offering targeted flea control with our dedicated cat flea meds for your furry companion
- LONG-LASTING FLEA PREVENTION FOR CATS: Protect your cat from infestations for up to 4 weeks with each application of this flea remover, providing continuous and reliable flea prevention for cats
- FAST-ACTING FLEA MEDICATION FOR CATS: Eliminates fleas in just 12 hours, providing your large cat with swift relief from discomfort with our effective flea medication for cats
$20.90
5
Best Value
11% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Frontline
11% Off

FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

Frontline

$39.98

$44.99
(11% Off)

More Details
Main highlights
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Cats can be used on kittens as young as eight weeks old, weighing 1.5 pounds or more; One monthly dose provides protection from fleas & ticks for a full 30 days
- Treat cats and dogs in the home monthly to effectively control fleas and ticks and prevent the establishment of new infestations
- Subscribe & save today to make it easier to keep your cat or dog protected year-round and make sure you never run out of FRONTLINE Plus
- FRONTLINE Plus for Cats provides waterproof, fast-acting, long-lasting flea and tick protection that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- FRONTLINE Plus also comes in a formula designed for dogs and puppies, 8 weeks and older, weighing 5 lbs and over, providing the same reliable flea & tick protection
- Even indoor dogs need flea and tick control because you or other pets in the household may bring fleas into the home; These fleas can lead to a flea infestation
- Break the flea life cycle with FRONTLINE Plus for Cats, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea & tick control
$39.98
$44.99 (11% Off)

Best flea treatment for cats - Holiday Sale 2025

Advantage XD Small Cat Flea Prevention & Treatment For Cats 1.8-9lbs. | 2-Topical Doses, 2-Months of Protection Per Dose

Capstar (nitenpyram) Cat Flea Treatment, Fast-Acting Oral Flea Treatment for Cats 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 6 Doses

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 1-Month Supply

Amazon Basics PreventativeTopical Flea Treatment for Large Cats (Over 9 Pounds), 4 Count

FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

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Amazon Basics PreventativeFlea and Tick Topical Treatment for Cats (Over 1.5 Pounds), 3 Count

Advantage Topical Cat Flea Treatment and Prevention for Small Cats 2-9 lbs. | Apply Flea Drops Monthly | 2 Treatments

Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention | Cats 5-9 lbs. | 1-Month Supply

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