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Best cold sore remedies - June 2026

Last Updated - June 4, 2026

1
Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Clear Probiotics

Lysine Cold Sore Treatment for Lips with Pre-Probiotics & VIT C | 1 Month Supply | Supercharged Lysine Capsules with Rhamnosus & Acidophilus for Cold Sores Relief, Skin + Gut Health & Immune Support

Clear Probiotics

$39.99

More Details
Main highlights
- Why Wait for a Cold Sore? Treat It From Within: Balms and patches only work after an outbreak. Our capsule formula works from the inside to help prevent cold sores before they start and put an end to recurrence if consumed daily as advised.
- Proudly Made in the USA – Trusted Quality You Deserve: Manufactured in the FDA-registered facility, Clear Wellness 360 is committed to full transparency with clinically studied ingredients in proven doses. Consistent daily use delivers the best results over time. Our Vegan, Non-GMO formulas are 3rd-party tested for purity, potency, and safety. with no artificial flavors, fillers, or colors.
- Effortless to Take, Easy to Stick With: Our small, smooth capsules are easy to take with no aftertaste, causing no burps and it is gentle on the stomach. Designed for everyday use without the discomfort of large pills or harsh formulas. Just two a day keeps cold sores away.
- Cutting-Edge Nutritional Support: This advanced blend combines optimal levels of L-Lysine, known to help reduce arginine availability, with Vitamin C and a pre-probiotic blend to support immune function and mucosal health, which are key in managing lip and mouth blister outbreaks.
- Better Gut Health Means No Cold Sores: Cold sores may also be linked to gut imbalance. Our formula combines clinically researched pre-probiotic blend and L-Lysine to help restore microbial balance in the gut and reduce triggers linked to lip and mouth outbreaks. Our users have mentioned smoother, more hydrated lips with reduced dryness or irritation.
$39.99
2
Best Value

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Abreva

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

Abreva

$32.00

$34.23
(7% Off)

More Details
Main highlights
- Portable Cold Sore Cream: Packaged in a convenient tube for on the go cold sore treatment
- Number 1 Dermatologist Recommended Cold Sore Treatment: Abreva Cream is a nonprescription cold sore medicine that shortens healing time (1)
- Number 1 Cold Sore Brand: Two 0.07 oz tubes of Abreva 10 Percent Docosanol Cold Sore Treatment
- Nothing Heals Fever Blisters Faster: 10 percent docosanol cream penetrates deep into skin to tackle cold sores at their source (1, 2, 3)
- Lip Cream Clinically Proven to Shorten Duration of Symptoms: Cold sore product shortens duration of tingling, pain, burning and itching associated with cold sores (1)
- HSA and FSA eligible product
- Can Heal in 2.5 Days: Fever blister cream contains 10 percent docosanol to shorten the duration of cold sore symptoms (1)
$32.00
$34.23 (7% Off)
3

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Abreva

Abreva Docosanol 10% Cream Tube, FDA Approved Treatment for Cold Sore/Fever Blister, 2 grams

Abreva

$15.87

More Details
Main highlights
- Portable Cold Sore Product: Packaged in a convenient tube for on the go cold sore treatment
- Number 1 Dermatologist Recommended Cold Sore Treatment: Abreva Cream is a nonprescription cold sore medicine approved by the FDA to shorten healing time (1)
- Number 1 Cold Sore Brand: One 0.07 oz tube of Abreva 10% Docosanol Cold Sore Treatment
- Nothing Heals Your Cold Sore Faster: Cold sore treatment penetrates deep into skin to tackle cold sores at their source (1, 2, 3)
- HSA and FSA eligible item. Medicare Advantage OTC (MAOTC) eligible. *OTC benefits and eligible products vary by plan. Check your plan for specific details.
- Clinically Proven to Shorten Duration of Symptoms: Cold sore product shortens duration of tingling, pain, burning and itching associated with cold sores (1)
- Can Heal in 2.5 Days: Fever blister lip cream contains 10% docosanol to shorten the duration of cold sore symptoms (1)
$15.87
4

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Mederma

Mederma Cold Sore Discreet Patch - Hydrocolloid Gel, Relieves Redness & Swelling, Conceals Cold Sores

Mederma

$12.97

$13.99
(7% Off)

More Details
Main highlights
- HSA and FSA eligible product
- Easy Application: Simple step-by-step instructions for applying the patch securely and comfortably. Wash hands thoroughly before and after applying the patch. Ensure the lip area is clean and dry, with no creams or ointments applied.
- Discreet Design: Translucent patch conceals cold sores, allowing you to go about your day with confidence. Acts like a barrier to reduce the risk of contamination and helps prevent cold sore from worsening.
- 12-Hour Protection: Each patch provides continuous protection for up to 12 hours.
$12.97
$13.99 (7% Off)
5

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Lyranda

Lyranda® - Lysine Cold Sore Treatment - Chewable L-Lysine Tablets - Faster Absorption and Better Hygiene

Lyranda

$19.95

More Details
Main highlights
- Supports Immune Health: Helps maintain a strong immune system and supports the body's natural defense against occasional cold symptoms.
- Gluten- and lactose-free: Made with high-quality, non-GMO ingredients, completely free from gluten, lactose, and unnecessary additives.
- Fast Acting Formula: Chewable form ensures faster absorption than creams or capsules, delivering quicker and more effective results.
- Easy to Take Anytime: Convenient, discreet, and portable tablets that can be taken effortlessly with or without food throughout the day.
- Chewable Tablets: Easy-to-chew tablets for discreet and hassle-free supplementation of 1000mg L-Lysine anytime, anywhere.
$19.95

Best cold sore remedies - June 2026

Lysine Cold Sore Treatment for Lips with Pre-Probiotics & VIT C | 1 Month Supply | Supercharged Lysine Capsules with Rhamnosus & Acidophilus for Cold Sores Relief, Skin + Gut Health & Immune Support

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

Abreva Docosanol 10% Cream Tube, FDA Approved Treatment for Cold Sore/Fever Blister, 2 grams

Mederma Cold Sore Discreet Patch - Hydrocolloid Gel, Relieves Redness & Swelling, Conceals Cold Sores

Lyranda® - Lysine Cold Sore Treatment - Chewable L-Lysine Tablets - Faster Absorption and Better Hygiene

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