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Best acetaminophens - Holiday Sale 2025

Last Updated - December 5, 2025

1
Best Choice

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Generic

Acetaminophen 500mg, Extra Strength Rapid Release, 400 Gelcaps

Generic

$29.99

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Main highlights
- Acetaminophen 500mg, Extra Strength Rapid Release, 400 Gelcaps
$29.99
2

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Generic

Extra Strength Acetaminophen 500mg Gelcaps – 400 Count (Pack of 1)

Generic

$27.44

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Main highlights
- Extra Strength Acetaminophen 500mg Gelcaps – 400 Count
$27.44
3
15% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basic Care
15% Off

Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count

Amazon Basic Care

$17.92

$21.30
(15% Off)

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Main highlights
- TEMPORARY PAIN RELIEF: This product may also be used to temporarily relieve other minor aches and pains due to: muscular aches, backache, premenstrual and menstrual cramps, the common cold, headache, toothache.
- PUSH & TURN CAP: The container has a child-resistant cap. This product is a pain reliever and fever reducer for adults. Under 18 years of age, ask a doctor.
- PURPOSE: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg is a pain reliever and fever reducer that can be used for the temporary relief of minor pain of arthritis.
- ASPIRIN FREE, GLUTEN FREE: Extended release caplets (capsule-shaped tablets) each provide 650 mg of acetaminophen, pain reliever and fever reducer, and contain no aspirin. Effective for minor arthritis pain. This product is gluten free.
- ACTIVE INGREDIENT: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg active ingredient is acetaminophen 650 mg,. Compare to the active ingredient in Tylenol 8HR Arthritis Pain.
$17.92
$21.30 (15% Off)
4
Best Value
19% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basic Care
19% Off

Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count

Amazon Basic Care

$15.78

$19.65
(19% Off)

More Details
Main highlights
- GLUTEN FREE: This pain reliever and fever reducer is free of gluten, aspirin and caffeine.
- FOR ADULTS: Amazon Basic Care Rapid Release Pain Relief, Acetaminophen Caplets 500 mg contain an extra strength pain reliever and fever reducer for adults and children ages 12 years and over
- EXTRA STRENGTH: These extra strength caplets are made for fast relief, with 500 mg of acetaminophen; package features a child-resistant cap
- EFFECTIVE: This product temporarily relieves minor aches and pains due to headache, muscular aches, backache, minor pain of arthritis, the common cold, toothache and premenstrual and menstrual cramps. Also temporarily reduces fever.
- ACTIVE INGREDIENT: Amazon Basic Care Rapid Release Acetaminophen 500 mg Caplets active ingredient is 500 mg of acetaminophen, a pain reliever and fever reducer. Compare to Tylenol Extra Strength Rapid Release Gels active ingredient.
$15.78
$19.65 (19% Off)
5

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

HealthA2Z

HealthA2Z® Extra Strength Pain Relief | Acetaminophen 500mg | Contains No Aspirin | Fever Reducer | Pain Reliever (500 Count (Pack of 1))

HealthA2Z

$9.99

More Details
Main highlights
- ✅ Trusted Everyday Relief: Safe and effective when used as directed for adults and children 12 years and older.
- ✅ Reduces Fever: Helps temporarily reduce fever and provide comfort during colds or flu.
- ✅ Gentle on Stomach: Contains no aspirin, caffeine, or ibuprofen — suitable for those with sensitive stomachs.
- ✅ Fast, Effective Pain Relief: Each caplet contains 500 mg of acetaminophen to relieve headaches, backaches, muscle aches, toothaches, and menstrual pain.
$9.99

Best acetaminophens - Holiday Sale 2025

Acetaminophen 500mg, Extra Strength Rapid Release, 400 Gelcaps

Extra Strength Acetaminophen 500mg Gelcaps – 400 Count (Pack of 1)

Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count

Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count

HealthA2Z® Extra Strength Pain Relief | Acetaminophen 500mg | Contains No Aspirin | Fever Reducer | Pain Reliever (500 Count (Pack of 1))

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