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Best methylfolates - May 2026

Last Updated - May 26, 2026

1
Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Carlyle

Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free Supplement | Methyl Folate, 5-MTHF | by Opti-Folate

Carlyle

$29.99

More Details
Main highlights
- ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living.
- NATURALLY FREE OF: Gluten, Wheat, Yeast, Lactose, Soy, Artificial Flavor, Preservatives and Non-GMO
- L-METHYLFOLATE: A metabolically active form of Folic Acid, also known as Folate or B-9 Vitamin!
- COMPLETE FORMULA: Quick-release capsules deliver 25,000 mcg Folate (15 mg L-METHYLFOLATE)
- CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
$29.99
2

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Micro Ingredients

Micro Ingredients L Methylfolate 15mg, 240 Softgels | Active 5-MTHF with B6 & Methyl B12 | Methylated Vitamin B9 with Coconut Oil

Micro Ingredients

$28.99

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Main highlights
- These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Premium non-GMO methylfolate supplement. Made without soy, dairy, and gluten. Ingredients must pass a 3rd party lab test to ensure our product is safe, pure, and potent.
- Micro Ingredients offers a highly bioavailable 3-in-1 L-Methylfolate softgel formula made with coconut oil for enhanced absorption, delivering active folate as 5-MTHF (25mg DFE containing 15mg L-Methylfolate) per serving with Vitamin B6 and Methyl B12.
- L-Methylfolate is the active form of folate, combined with methylated B12 (1,000mcg as methylcobalamin) and Vitamin B6 (as pyridoxine HCl) in a powerful active formula to support efficient nutrient utilization.
- Enjoy complementary 3-in-1 support with a complex of key B vitamins that work together to promote mood, heart, energy, and brain health for both men and women.
- Each pouch includes 240 softgels, with 2 softgels per serving, providing a 120-day supply of advanced B vitamin replenishment over time.
$28.99
3

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Triquetra Health

L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)

Triquetra Health

$21.97

More Details
Main highlights
- VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
- SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.
- SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
- HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
- ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
$21.97
4
Best Value
10% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Triquetra Health
10% Off

L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)

Triquetra Health

$19.77

$21.97
(10% Off)

More Details
Main highlights
- VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
- SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.
- SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
- HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
- ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
$19.77
$21.97 (10% Off)
5

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Triquetra Health

L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)

Triquetra Health

$21.97

More Details
Main highlights
- VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
- SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.
- SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
- HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
- ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
$21.97

Best methylfolates - May 2026

Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free Supplement | Methyl Folate, 5-MTHF | by Opti-Folate

Micro Ingredients L Methylfolate 15mg, 240 Softgels | Active 5-MTHF with B6 & Methyl B12 | Methylated Vitamin B9 with Coconut Oil

L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)

L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)

L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)

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