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Best heartworm prevention for dogs - Holiday Sale 2025

Last Updated - December 14, 2025

1
Best Choice

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

HEARTGARD

HEARTGARD® Plus (ivermectin/pyrantel) Real-Beef Chewables for Dogs 51-100 lbs (Brown Box) 6 Month Supply of Chews (Heartworm Disease Preventive)

HEARTGARD

$83.89

More Details
Main highlights
- Vet-recommended heartworm preventive
- From the brand trusted over 2.5 billion times⁵
- Effectively prevents heartworm disease
- Delicious once a month real-beef chew that dogs love⁶
- Also treats and controls roundworms & hookworms
$83.89
2

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

K9 Advantix

K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 lbs. | 4-Mo Supply

K9 Advantix

$57.48

More Details
Main highlights
- Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
- No prescription needed
- Kills fleas within 12 hours of application
- K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
- Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
$57.48
3

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

HEARTGARD

HEARTGARD® Plus (ivermectin/pyrantel) Real-Beef Chewables for Dogs up to 25 lbs (Blue Box) 6 Month Supply of Chews (Heartworm Disease Preventive)

HEARTGARD

$56.49

More Details
Main highlights
- Vet-recommended heartworm preventive
- From the brand trusted over 2.5 billion times
- Effectively prevents heartworm disease
- Delicious once a month real-beef chew that dogs love
- Also treats and controls roundworms & hookworms
$56.49
4

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

TRI-HEART PLUS

TRI-HEART PLUS Chewable Tablet for Dogs, 26-50 lbs (Green Box), 6 Chewable Tablets, 6-Month Supply

TRI-HEART PLUS

$36.99

More Details
Main highlights
- Safe for dogs with beef allergies
- Prevents heartworm disease, treats, and controls roundworms and hookworms
- Kills heartworm larvae before they reach your dog’s heart
- Enjoy year-round protection for your dog, with monthly treatments
- Easy-to-give, beef-flavored, chewable tablet that your dog will enjoy.
$36.99
5
Best Value

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

PetArmor

PetArmor 7 Way De-Wormer for Dogs, Oral Treatment for Tapeworm, Roundworm & Hookworm in Large Dogs & Puppies (Over 25 lbs), Worm Remover (Praziquantel & Pyrantel Pamoate), 6 Flavored Chewables

PetArmor

$43.99

More Details
Main highlights
- Vet Quality: These vet-quality dog tapeworm dewormer tablets are safe for puppies 12 weeks or older, and large dogs 25.1 to 200 lbs
- Recommended Use: For best results with PetArmor canine dewormer, read and follow label instructions; if you need to retreat your dog, we recommend consulting with your veterinarian and performing a fecal test to rule out any other issues or parasites
- How to Use: Watch your dog for a few minutes after dosing to make sure the chewable dog dewormer is not rejected and the full dose of deworming for dogs is eaten
- Dewormer for Dogs: PetArmor 7 Way Chewable dewormer for puppies; treats and controls 7 species of worms: 2 types of tapeworms, 2 types of roundworms, and 3 types of hookworms in dogs 12 weeks and older.
- Dewormer Tablets: PetArmor broad spectrum dewormer comes in chewable tablets that provide pyrantel pamoate for dogs, making it easy and convenient to give
$43.99

Best heartworm prevention for dogs - Holiday Sale 2025

HEARTGARD® Plus (ivermectin/pyrantel) Real-Beef Chewables for Dogs 51-100 lbs (Brown Box) 6 Month Supply of Chews (Heartworm Disease Preventive)

K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 lbs. | 4-Mo Supply

HEARTGARD® Plus (ivermectin/pyrantel) Real-Beef Chewables for Dogs up to 25 lbs (Blue Box) 6 Month Supply of Chews (Heartworm Disease Preventive)

TRI-HEART PLUS Chewable Tablet for Dogs, 26-50 lbs (Green Box), 6 Chewable Tablets, 6-Month Supply

PetArmor 7 Way De-Wormer for Dogs, Oral Treatment for Tapeworm, Roundworm & Hookworm in Large Dogs & Puppies (Over 25 lbs), Worm Remover (Praziquantel & Pyrantel Pamoate), 6 Flavored Chewables

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