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Best enzymatic cleaner for dog urines - Holiday Sale 2025

Last Updated - December 14, 2025

1
Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon

Picked by 686 people in the last week

Rocco & Roxie Supply Co.

$59.97

More Details
Main highlights
- Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
- Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
- Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
- Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
- Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it right
$59.97
2

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Nature's Miracle

Nature’s Miracle Advanced Stain And Odor Eliminator for Dogs, Fresh Scent, Severe Mess Enzymatic Formula For Tough Pet Messes, 1 Gallon

Nature's Miracle

$35.07

More Details
Main highlights
- included components: PHL309579
- age range description: Adult
- Light fresh scent
- For use on carpets, hard floors, furniture, clothing and more
- Fast-drying
- Enzymatic formula for severe messes
- Discourages re-soiling by removing the odor of the toughest messes
$35.07
3

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Bioda

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

Bioda

$25.99

More Details
Main highlights
- THE POWER OF ONE: This versatile product is the only probiotic cleaner you need, providing powerful cleaning performance in a wide variety of applications. Multipurpose use: Maintain clean drain lines and septic tanks to prevent clogs and potential buildup. Clean and deodorize trash bins, stains and odors on floors, carpets, bathroom surfaces, kitchen surfaces, and more.
- NATURALLY, SUPERIOR RESULTS: A special blend of enzyme-producing probiotics break down complex proteins, fats, oils, greases, and other organic waste. The enzymes digest the soils until they have been eliminated, providing a long-lasting, continuous clean without leaving a residue or harmful by-products behind.
- MADE IN THE USA - 1 Gallon Bottle
- ELIMINATE ODOR: Provide total odor control by eliminating the actual source of even the most pungent organic malodors naturally, including rotting food, urine, feces, vomit, and trash. Plus, the fresh lemon and sage fragrance leaves behind a light, pleasant scent that rejuvenates the air of any environment.
- ACTIVE UP TO 21 DAYS: Our specialized probiotics continue to clean soils in cracks, grout and tough to reach places. Simply spray & let the probiotics do the dirty work!
$25.99
4

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

AmazonCommercial

AmazonCommercial Multi-Purpose Enzyme Cleaner, 1-Gallon, 1-Pack

AmazonCommercial

$33.29

More Details
Main highlights
- Use as needed on stains and problem areas for spot cleaning carpet, surfaces, drains, toilets, grease traps, and more
- Ideal for commercial properties, retail, and hospitality
- Breaks up complex organic proteins, pet smells and stains, hair, grease, oils, and more for effective results
- 1 gallon bottle of multi-purpose enzyme cleaning solution for a wide variety of surfaces and environments
$33.29
5
Best Value
15% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Nature's Miracle
15% Off

Nature's Miracle Stain and Odor Remover for Dogs, Odor Control Formula, Refill, 1.33 Gal

Nature's Miracle

$27.45

$32.49
(15% Off)

More Details
Main highlights
- TOUGH ON STAINS AND ODORS: This stain and odor remover is tough on dog urine, feces, vomit, drool and other organic stains and odors.
- SAFE FOR PETS AND HOME: We’ve been loved by pet parents for over 35 years, so we know the importance of having an effective stain and odor remover that, when used and stored as directed, is safe to use around pets.
- MULTI-SURFACE USE: When used and stored as directed, this product is safe for use on carpets, hard floors, furniture, fabrics and more.
- CITRUS SCENT: In addition to removing stains and odors, this product freshens with a light citrus scent.
$27.45
$32.49 (15% Off)

Best enzymatic cleaner for dog urines - Holiday Sale 2025

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon

Nature’s Miracle Advanced Stain And Odor Eliminator for Dogs, Fresh Scent, Severe Mess Enzymatic Formula For Tough Pet Messes, 1 Gallon

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

AmazonCommercial Multi-Purpose Enzyme Cleaner, 1-Gallon, 1-Pack

Nature's Miracle Stain and Odor Remover for Dogs, Odor Control Formula, Refill, 1.33 Gal

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